Benefits of Bio-identical

Hormone Replacement Therapy

Our hormones are fundamental to everyday life, and changes in their balance require special management, whether it be due to a medical condition or a specific stage of life.

As men and women age, hormone levels – testosterone, estrogen, and others – naturally decline. However, hormone imbalance may happen to people as early as their 20s and beyond, due to the vast amount of toxins that enter the body from the environment, chemicals we consume in everyday products and toxic, stressful relationships.

The EvexiPEL method of bio-identical hormone replacement therapy (BHRT) with pellets provides a superior approach to optimize hormones and address health conditions and symptoms associated with unbalanced hormones in women and men.

EvexiPEL's Method Of Subcutaneous BHRT Provides Numerous Benefits

BHRT with pellets is typically much more convenient for patients. Unlike traditional BHRT treatments – creams, patches, pills, and injections – many men and women prefer pellet therapy because the treatment offers:


Instead of daily treatments, most patients only have to visit a practitioner 2-3 times per year for pellet implants.


While convenience is important to patients, successfully alleviating the symptoms of imbalanced hormones is one of the main reasons patients turn to EvexiPEL practitioners for help. Thanks to the integrated approach implemented by EvexiPEL providers, patients can discover the underlying causes of their health concerns and receive a more balanced treatment plan which increases the likelihood of long-lasting positive results for their wellbeing.

Pellets deliver a steady stream of hormones – when the body needs it – mimicking the way the body naturally releases hormones.

While convenience is important to EvexiPEL patients, successfully alleviating the symptoms of imbalanced hormones is one of the main reasons patients turn to EvexiPEL practitioners for help.



Yes! After a decade treating thousands of patients, EvexiPEL founder Terri DeNeui, MSN, APRN-BC worked diligently with a team of experts at FarmaKeio to develop a proprietary pellet formula. The EvexiPEL method favors pellets from leading compound pharmacy, FarmaKeio, but ultimately EvexiPEL providers are free to utilize any BHRT pellet they feel will best serve their patients’ needs. While FarmaKeio’s pellets have not been studied or approved by the FDA, many providers have reported patient satisfaction and impressive results.

The practitioner makes a tiny incision – usually in the buttocks or flank – then inserts the pellets into the fatty tissue under the skin. The practitioner then closes the incision, without the need for stitches. To prevent patient discomfort, a local anesthetic is applied to the insertion site prior to the procedure.

In response to physical activity or emotional stress (whether it’s good stress or bad), the pellets release estradiol and/or testosterone into the body. Thanks to the pellets, which are securely tucked away beneath the skin, the patient receives a steady stream of hormones, which keeps annoying mood and energy fluctuations at bay.

Yes! And the EvexiPEL formulation has been shown to produce better outcomes for patients, too. After a decade treating thousands of patients, EvexiPEL founder Terri DeNeui, MSN, APRN-BC worked diligently with a team of experts to develop a proprietary pellet formula.

Put into practice at one of the largest known hormone pellet therapy providers in the country –EVEXIAS Medical Centers – the formulation yielded the following results:

  • Reduced Scar Tissue.
  • Less Boosts Required in new patients.
  • Fewer Office Visits.
  • Quicker and More Consistent Absorption.

Increased practitioner and patient satisfaction. Period.

EvexiPEL: An Evolved Approach to Balancing Hormones

Unlike other BHRT providers, EvexiPEL practitioners take a functional approach to treating patients with hormone imbalance. After years of treating thousands of patients, digging deep to find the root cause of patient health concerns and intensive research, DeNeui found that some patients don’t respond to BHRT with subcutaneous pellets alone.

Over the years, DeNeui and her team of practitioners have discovered that hormone imbalance is but one factor that may contribute to patients’ health struggles. The mind, body, and spirit all need to be addressed for the patient to heal fully. Key insights include:



Recent research has revealed that how we metabolize hormones is hardwired in our DNA. Practitioners need to be aware that some patients have more difficulty metabolizing hormones, so treatment plans need to be modified accordingly.



Practitioners need to talk with patients about the toxins they’re exposed to in their day-to-day lives, then counsel them on steps to take to remove them. Toxicity goes beyond the food, fluids, chemicals and pollution we consume or breath in – toxic relationships and jobs lead to unnecessary stress and anxiety that makes people vulnerable to illness and chronic disease.

Gut Health

Gut Health

Research has revealed there is a direct connection between gut health and inflammation, autoimmune disorders, mental health and more. It’s also essential to have a healthy gut in order to metabolize hormones efficiently. Thus, while uncovering the root cause of the patient’s health issues, practitioners must closely analyze the patient’s gut health and prescribe the appropriate detox program, probiotics, nutrients and supplements to restore gut health.

“Today we take a much more integrated approach to treating patients than in the past. Experts in hormone optimization, functional medicine, nutrition and mental health work as a team so patients experience optimum results.”

Terri DeNeui, DNP, ACNP, APRN-BC
EvexiPEL founder

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